PF3D7_1011100

Genome location: Pf3D7_10_v3:432,120..436,309(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.13	0.93
Trophozoite	expressed	0.26	0.83
Schizont	expressed	0.08	0.94
Gametocyte	not expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1011100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.151 | MFS: -2.845 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1209500)

Relative Growth Rate: 0.09 ± 0.14
Confidence: 5.25

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJT4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533047

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	43	34	66
disruptive	50	145	73	165
missense	32	116	57	125

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	98	38	76
disruptive	86	310	148	281
missense	54	234	109	163

PlasmoDB Total SNPs: 253

Non-coding: 123 | Synonymous: 71 | Nonsynonymous: 59 | Stop Codon: 0

Protein Information

Protein Length: 983 | Molecular Weight (kDa): 118.884

UniProt ID(s): Q8IJT4

PDB ID(s): None

Isoelectric Point: 6.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A