PF3D7_1011200 (BET1)

Genome location: Pf3D7_10_v3:436,924..437,944(+)

Genome classification: Core

Function and Localization

Product Description: BET1-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0031201	SNARE complex
Function	GO:0005484	SNAP receptor activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	nd	nd
Trophozoite	not expressed	nd	nd
Schizont	not expressed	nd	nd
Gametocyte	not expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1011200.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.128 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJT3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101026

Most Similar Human Ortholog: H7BXT7

TM-align score: 0.82 | RMSD: 1.09

Seq Identity: 0.10 | Length: 51 / 114

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000105829	Bet1 golgi vesicular membrane trafficking protein
ENSG00000177951	Bet1 golgi vesicular membrane trafficking protein like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	4	4	6
disruptive	2	11	7	10
missense	2	11	7	9

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	13	4	9
disruptive	6	21	9	26
missense	5	17	8	18

PlasmoDB Total SNPs: 45

Non-coding: 41 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 114 | Molecular Weight (kDa): 13.901

UniProt ID(s): Q8IJT3

PDB ID(s): None

Isoelectric Point: 10.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000727	Target SNARE coiled-coil homology domain
InterPro	IPR039897	BET1-like protein
PFam	N/A	N/A
Superfamily	SSF58038	N/A