Product Description: protein ARV1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 5
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0032541 | cortical endoplasmic reticulum |
| Process | GO:0032366 | intracellular sterol transport |
| Process | GO:0097036 | regulation of plasma membrane sterol distribution |
| Process | GO:0006665 | sphingolipid metabolic process |
| Process | GO:0016125 | sterol metabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.96 |
| Trophozoite | not expressed | 0.43 | 0.74 |
| Schizont | not expressed | 0.28 | 0.82 |
| Gametocyte | not expressed | 0.38 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1011300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.13 | MFS: -3.144 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1209700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJT2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104234
Most Similar Human Ortholog: A0A0A0MRI7
TM-align score: 0.41 | RMSD: 4.41
Seq Identity: 0.10 | Length: 128 / 644
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000173409 | ARV1 homolog, fatty acid homeostasis modulator |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 33 | 21 | 37 |
| disruptive | 16 | 60 | 32 | 72 |
| missense | 6 | 50 | 25 | 60 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 66 | 28 | 42 |
| disruptive | 33 | 141 | 57 | 116 |
| missense | 14 | 104 | 42 | 80 |
PlasmoDB Total SNPs: 111
Non-coding: 49 | Synonymous: 41 | Nonsynonymous: 21 | Stop Codon: 0
Protein Length: 644 | Molecular Weight (kDa): 78.006
UniProt ID(s): Q8IJT2
PDB ID(s): None
Isoelectric Point: 9.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007290 | Arv1 protein |
| PFam | PF04161 | Arv1 protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32449190 | Cold-sensitive phenotypes of a yeast null mutant of ARV1 support its role as aGPI flippase | Okai H, Ikema R, ..., Funato K | 10.1002/1873-3468.13843 |
| 33735232 | Proteomic identification of the UDP-GlcNAc: PI alpha1-6 GlcNAc-transferase subunitsof the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei | Ji Z, Tinti M, Ferguson MAJ | 10.1371/journal.pone.0244699 |
| 35369708 | Mediator Engineering of Saccharomyces cerevisiae To Improve MultidimensionalStress Tolerance | Qi Y, Xu N, ..., Liu L | 10.1128/aem.01627-21 |