PF3D7_1011600

Genome location: Pf3D7_10_v3:445,004..447,552(-)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.10	0.95
Trophozoite	possibly expressed	0.21	0.87
Schizont	not expressed	0.07	0.95
Gametocyte	not expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1011600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.707 | #Insertions: 8

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1210000)

Relative Growth Rate: 1.03 ± 0.18
Confidence: 4.86

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1210000)

Modification: Disrupted | RMgm-3213

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJS9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532755

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	27	19	35
disruptive	11	50	37	110
missense	11	50	35	103

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	63	22	50
disruptive	22	130	84	152
missense	15	109	79	122

PlasmoDB Total SNPs: 99

Non-coding: 45 | Synonymous: 40 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 653 | Molecular Weight (kDa): 78.187

UniProt ID(s): Q8IJS9

PDB ID(s): None

Isoelectric Point: 8.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A