About Gene List

PF3D7_1012100

Genome location: Pf3D7_10_v3:467,551..470,056(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.08 0.96
Trophozoite expressed 0.45 0.74
Schizont expressed 0.38 0.76
Gametocyte expressed 0.49 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1012100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.183 | MFS: -2.843 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1210500)

  • Relative Growth Rate: 0.09 ± 0.06
  • Confidence: 6.98

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJS4

"Best" AlphaFill ligand hit: NAP (nadp nicotinamide-adenine-dinucleotide phosphate, Local RMSD=10.83) with 8CB0 (Global RMSD=15.88)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134704

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 21 18 30
disruptive 3 22 23 57
missense 3 22 22 51

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 44 26 19
disruptive 9 62 47 72
missense 7 52 41 62

PlasmoDB Total SNPs: 111

Non-coding: 97 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 1

Protein Information

Protein Length: 387 | Molecular Weight (kDa): 47.179

UniProt ID(s): Q8IJS4

PDB ID(s): None

Isoelectric Point: 10.29

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21