Product Description: rhoptry associated adhesin
SignalP Peptide: MKRFFVLFVIFLVHIWSENVDT
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0009986 | cell surface |
| Component | GO:0020008 | rhoptry |
| Function | GO:0046812 | host cell surface binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.08 | 0.95 |
| Schizont | expressed | 2.14 | 0.27 |
| Gametocyte | expressed | 0.24 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1012200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.165 | MFS: -2.882 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1210600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1210600)
Modification: Disrupted | RMgm-3219
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJS3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 10 | 7 | 22 |
| disruptive | 6 | 27 | 17 | 52 |
| missense | 4 | 23 | 14 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 30 | 13 | 22 |
| disruptive | 22 | 76 | 41 | 80 |
| missense | 7 | 63 | 34 | 48 |
PlasmoDB Total SNPs: 111
Non-coding: 98 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 267 | Molecular Weight (kDa): 31.791
UniProt ID(s): Q8IJS3
PDB ID(s): None
Isoelectric Point: 7.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 27383149 | A novel Plasmodium falciparum rhoptry associated adhesin mediates erythrocyteinvasion through the sialic-acid dependent pathway. | Anand G, Reddy KS, ..., Gaur D | 10.1038/srep29185 |