Product Description: cytochrome b-c1 complex subunit 7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.10.2.2 (Transferred entry: 7.1.1.8)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005750 | mitochondrial respiratory chain complex III |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0009060 | aerobic respiration |
| Process | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c |
| Process | GO:0034551 | mitochondrial respiratory chain complex III assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.51 | 0.69 |
| Schizont | expressed | 0.69 | 0.60 |
| Gametocyte | expressed | 0.96 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1012300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.18 | MFS: -2.624 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1210700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJS2
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.10.2.2 | quinol-cytochrome-c reductase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 106
Non-coding: 91 | Synonymous: 14 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 192 | Molecular Weight (kDa): 23.02
UniProt ID(s): Q8IJS2
PDB ID(s): None
Isoelectric Point: 9.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003197 | Cytochrome b-c1 complex subunit 7 |
| InterPro | IPR036544 | Cytochrome b-c1 complex subunit 7 superfamily |
| PFam | PF02271 | Cytochrome b-c1 complex subunit 7 |
| Superfamily | SSF81524 | Cytochrome b-c1 complex subunit 7 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 30926815 | Phosphatidylethanolamine made in the inner mitochondrial membrane is essentialfor yeast cytochrome bc(1) complex function | Calzada E, Avery E, ..., Claypool SM | 10.1038/s41467-019-09425-1 |
| 14718526 | Human disease-related mutations in cytochrome b studied in yeast | Fisher N, Castleden CK, ..., Meunier B | 10.2.- |
| 29475949 | Cbp3 and Cbp6 are dispensable for synthesis regulation of cytochrome b in yeastmitochondria | Garcia-Guerrero AE, Camacho-Villasana Y, ..., Perez-Martinez X | 10.1074/jbc.RA117.000547 |
| 7948033 | Isolation and characterisation of the linked genes APA2 and QCR7, coding for Ap4Aphosphorylase II and the 14 kDa subunit VII of the mitochondrial bc1-complex inthe yeast Kluyveromyces lactis | Mulder W, Scholten IH, van Roon H, Grivell LA | 10.1016/0167-4781(94)90235-6 |
| 20832886 | Increased biomass production of industrial bakers' yeasts by overexpression ofHap4 gene | Duenas-Sanchez R, Codon AC, Rincon AM, Benitez T | 10.1016/j.ijfoodmicro.2010.08.009 |
| 34052951 | Overexpression of a single ORF can extend chronological lifespan in yeast ifretrograde signaling and stress response are stimulated | Pogoda E, Tutaj H, ..., Korona R | 10.1007/s10522-021-09924-z |
| 10873857 | Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeastSaccharomyces cerevisiae co-crystallized with an antibody Fv fragment | Hunte C, Koepke J, ..., Michel H | 10.1016/s0969-2126(00)00152-0 |
| 8125116 | The C-terminus of the 14-kDa subunit of ubiquinol-cytochrome-c oxidoreductase ofthe yeast Saccharomyces cerevisiae is involved in the assembly of a functionalenzyme | Hemrika W, De Jong M, Berden JA, Grivell LA | 10.1111/j.1432-1033.1994.tb18657.x |
| 11556807 | The functional role of conserved acidic residues of the Qcr7 protein of thecytochrome bc(1) complex in Saccharomyces cerevisiae | Lee SY, Raha S, Nagar B, Robinson BH | 10.2.- |
| 9211895 | The N terminus of the Qcr7 protein of the cytochrome bc1 complex is not essentialfor import into mitochondria in Saccharomyces cerevisiae but is essential forassembly of the complex | Malaney S, Trumpower BL, Deber CM, Robinson BH | 10.1074/jbc.272.28.17495 |