About Gene List

PF3D7_1013000

Genome location: Pf3D7_10_v3:499,604..502,530(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0071944 cell periphery

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.08 0.96
Trophozoite expressed 0.17 0.89
Schizont expressed 0.35 0.77
Gametocyte expressed 0.30 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1013000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.713 | MFS: -0.407 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1211400)

Modification: Disrupted | RMgm-3225

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJR5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_144794

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 25 17 47
disruptive 8 77 46 105
missense 8 73 45 93

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 66 28 41
disruptive 26 158 74 148
missense 23 137 67 79

PlasmoDB Total SNPs: 132

Non-coding: 96 | Synonymous: 24 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 520 | Molecular Weight (kDa): 61.678

UniProt ID(s): Q8IJR5

PDB ID(s): None

Isoelectric Point: 8.76

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR008974 TRAF-like
PFam N/A N/A
Superfamily SSF49599 TRAF-like
Superfamily SSF57850

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
27503796 Proteome mapping of Plasmodium: identification of the P. yoelii remodellome. Siau A, Huang X, ..., Preiser PR 10.1038/srep31055