PF3D7_1013100 (UTP13)

Genome location: Pf3D7_10_v3:502,323..508,664(-)

Genome classification: Core

Function and Localization

Product Description: U3 small nucleolar RNA-associated protein 13, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030686	90S preribosome
Component	GO:0005730	nucleolus
Component	GO:0032040	small-subunit processome
Function	GO:0034511	U3 snoRNA binding
Process	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Process	GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.98	0.58
Trophozoite	expressed	0.86	0.54
Schizont	not expressed	0.33	0.81
Gametocyte	expressed	0.63	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1013100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.035 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJR4

"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=0.36) with 4GM3 (Global RMSD=6.69)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102171

Most Similar Human Ortholog: Q12788

TM-align score: 0.71 | RMSD: 4.73

Seq Identity: 0.17 | Length: 670 / 1220

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000183751	transducin beta like 3

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	61	41	84
disruptive	25	145	90	230
missense	20	135	79	205

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	136	62	108
disruptive	67	339	169	331
missense	41	282	152	235

PlasmoDB Total SNPs: 200

Non-coding: 118 | Synonymous: 52 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 1220 | Molecular Weight (kDa): 144.605

UniProt ID(s): Q8IJR4

PDB ID(s): None

Isoelectric Point: 6.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
InterPro	IPR013934	Small-subunit processome, Utp13
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF00400	WD40 repeat
PFam	PF08625	Small-subunit processome, Utp13
Superfamily	SSF50978	WD40-repeat-containing domain superfamily
Superfamily	SSF50998	Quinoprotein alcohol dehydrogenase-like superfamily