About Gene List

PF3D7_1013300

Genome location: Pf3D7_10_v3:515,235..518,137(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005789 endoplasmic reticulum membrane
Process GO:0009966 regulation of signal transduction

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.23 0.89
Trophozoite expressed 0.70 0.61
Schizont expressed 0.16 0.89
Gametocyte not expressed 0.13 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1013300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.559 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJR2

"Best" AlphaFill ligand hit: DTP (, Local RMSD=0.06) with 6PWY (Global RMSD=16.23)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104880

Most Similar Human Ortholog: K7EMW4

TM-align score: 0.81 | RMSD: 3.16

Seq Identity: 0.16 | Length: 442 / 628

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000125912 nicalin

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 28 16 38
disruptive 13 83 53 127
missense 13 82 52 114

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 52 35 30
disruptive 29 190 102 202
missense 21 167 90 137

PlasmoDB Total SNPs: 86

Non-coding: 54 | Synonymous: 19 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 628 | Molecular Weight (kDa): 75.469

UniProt ID(s): Q8IJR2

PDB ID(s): None

Isoelectric Point: 9.7

Protein Domain Annotations:

Source Family ID Description
InterPro IPR016574 Nicalin
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097