PF3D7_1013300

Genome location: Pf3D7_10_v3:515,235..518,137(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005789	endoplasmic reticulum membrane
Process	GO:0009966	regulation of signal transduction

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.23	0.89
Trophozoite	expressed	0.70	0.61
Schizont	expressed	0.16	0.89
Gametocyte	not expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1013300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.559 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJR2

"Best" AlphaFill ligand hit: DTP (, Local RMSD=0.06) with 6PWY (Global RMSD=16.23)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104880

Most Similar Human Ortholog: K7EMW4

TM-align score: 0.81 | RMSD: 3.16

Seq Identity: 0.16 | Length: 442 / 628

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000125912	nicalin

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	28	16	38
disruptive	13	83	53	127
missense	13	82	52	114

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	52	35	30
disruptive	29	190	102	202
missense	21	167	90	137

PlasmoDB Total SNPs: 86

Non-coding: 54 | Synonymous: 19 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 628 | Molecular Weight (kDa): 75.469

UniProt ID(s): Q8IJR2

PDB ID(s): None

Isoelectric Point: 9.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016574	Nicalin
PFam	N/A	N/A
Superfamily	N/A	N/A