About Gene List

PF3D7_1013700

Genome location: Pf3D7_10_v3:540,590..541,993(+)

Genome classification: Core

Function and Localization

Product Description: thioredoxin-like protein, putative

SignalP Peptide: MFLLCLLLWRNIICDI

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.02 0.99
Trophozoite expressed 0.10 0.93
Schizont possibly expressed 0.07 0.95
Gametocyte expressed 0.22 0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1013700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1212100)

  • Relative Growth Rate: 0.07 ± 0.04
  • Confidence: 7.66

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1212100)

Modification: Tagged | RMgm-4529

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJQ8

"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=7.42) with 4IV8 (Global RMSD=14.85)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134715

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 5 7 20
disruptive 4 29 14 28
missense 4 28 13 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 21 9 18
disruptive 13 49 25 60
missense 10 42 23 43

PlasmoDB Total SNPs: 46

Non-coding: 40 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 191 | Molecular Weight (kDa): 23.439

UniProt ID(s): Q8IJQ8

PDB ID(s): None

Isoelectric Point: 9.23

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036249 Thioredoxin-like superfamily
PFam N/A N/A
Superfamily SSF52833 Thioredoxin-like superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30232409 An in silico down-scaling approach uncovers novel constituents of thePlasmodium-containing vacuole. Matz JM, Matuschewski K 10.1038/s41598-018-32471-6