Product Description: thioredoxin-like protein, putative
SignalP Peptide: MFLLCLLLWRNIICDI
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005737 | cytoplasm |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | possibly expressed | 0.02 | 0.99 |
Trophozoite | expressed | 0.10 | 0.93 |
Schizont | possibly expressed | 0.07 | 0.95 |
Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1013700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.13 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1212100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1212100)
Modification: Tagged | RMgm-4529
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJQ8
"Best" AlphaFill ligand hit: SAM (s-adenosylmethionine, Local RMSD=7.42) with 4IV8 (Global RMSD=14.85)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 5 | 7 | 20 |
disruptive | 4 | 29 | 14 | 28 |
missense | 4 | 28 | 13 | 26 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 0 | 21 | 9 | 18 |
disruptive | 13 | 49 | 25 | 60 |
missense | 10 | 42 | 23 | 43 |
PlasmoDB Total SNPs: 46
Non-coding: 40 | Synonymous: 3 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 191 | Molecular Weight (kDa): 23.439
UniProt ID(s): Q8IJQ8
PDB ID(s): None
Isoelectric Point: 9.23
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR036249 | Thioredoxin-like superfamily |
PFam | N/A | N/A |
Superfamily | SSF52833 | Thioredoxin-like superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
30232409 | An in silico down-scaling approach uncovers novel constituents of thePlasmodium-containing vacuole. | Matz JM, Matuschewski K | 10.1038/s41598-018-32471-6 |