About Gene List

PF3D7_1013800

Genome location: Pf3D7_10_v3:542,175..545,149(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.07 0.96
Trophozoite expressed 0.12 0.93
Schizont expressed 1.98 0.29
Gametocyte expressed 0.25 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1013800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 2.082 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1212200)

Modification: Disrupted | RMgm-3231

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJQ7

"Best" AlphaFill ligand hit: PTY (phosphatidylethanolamine, Local RMSD=0.36) with 2VWA (Global RMSD=26.79)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533006

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 25 12 37
disruptive 13 64 42 120
missense 8 50 35 99

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 53 16 38
disruptive 27 173 73 173
missense 15 128 55 122

PlasmoDB Total SNPs: 111

Non-coding: 65 | Synonymous: 28 | Nonsynonymous: 17 | Stop Codon: 1

Protein Information

Protein Length: 486 | Molecular Weight (kDa): 58.378

UniProt ID(s): Q8IJQ7

PDB ID(s): None

Isoelectric Point: 5.74

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104