Product Description: translation initiation factor eIF-2B subunit delta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.3.1.23 (S-methyl-5-thioribose-1-phosphate isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005851 | eukaryotic translation initiation factor 2B complex |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0006446 | regulation of translational initiation |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.48 | 0.77 |
| Trophozoite | not expressed | 0.68 | 0.62 |
| Schizont | not expressed | 0.33 | 0.79 |
| Gametocyte | not expressed | 0.53 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1013900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.029 | #Insertions: 6
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1212300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1212300)
Modification: Disrupted | RMgm-3232
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJQ6
"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.16) with 5YFV (Global RMSD=1.48)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.3.1.23 | S-methyl-5-thioribose-1-phosphate isomerase | RNAi |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101847
Most Similar Human Ortholog: Q9UI10
TM-align score: 0.63 | RMSD: 3.87
Seq Identity: 0.23 | Length: 368 / 1074
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115211 | eukaryotic translation initiation factor 2B subunit delta |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 71 | 30 | 59 |
| disruptive | 17 | 105 | 63 | 160 |
| missense | 16 | 95 | 57 | 131 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 123 | 34 | 80 |
| disruptive | 42 | 247 | 124 | 287 |
| missense | 31 | 196 | 101 | 187 |
PlasmoDB Total SNPs: 91
Non-coding: 20 | Synonymous: 45 | Nonsynonymous: 25 | Stop Codon: 1
Protein Length: 1074 | Molecular Weight (kDa): 125.379
UniProt ID(s): Q8IJQ6
PDB ID(s): None
Isoelectric Point: 9.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000649 | Initiation factor 2B-related |
| InterPro | IPR037171 | NagB/RpiA transferase-like |
| PFam | PF01008 | Initiation factor 2B-related |
| Superfamily | SSF100950 | NagB/RpiA transferase-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |