Product Description: GDP-L-fucose synthase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.1.1.271 (GDP-L-fucose synthase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0050577 | GDP-L-fucose synthase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | possibly expressed | 0.09 | 0.94 |
| Schizont | not expressed | 0.20 | 0.88 |
| Gametocyte | not expressed | 0.14 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1014000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.136 | MFS: -2.471 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1212400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1212400)
Modification: Disrupted | RMgm-3233
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZXB3
"Best" AlphaFill ligand hit: NAP (nadp nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.44) with 6AQZ (Global RMSD=2.73)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.1.1.271 | GDP-L-fucose synthase | GDPNADPGDP-fucose6-alkynyl-fucose |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102554
Most Similar Human Ortholog: Q13630
TM-align score: 0.96 | RMSD: 1.31
Seq Identity: 0.39 | Length: 316 / 344
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104522 | GDP-L-fucose synthase |
| ENSG00000278243 | GDP-L-fucose synthase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 18 | 8 | 21 |
| disruptive | 1 | 10 | 8 | 24 |
| missense | 1 | 10 | 8 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 31 | 22 | 15 |
| disruptive | 1 | 38 | 25 | 53 |
| missense | 1 | 35 | 18 | 42 |
PlasmoDB Total SNPs: 82
Non-coding: 74 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 344 | Molecular Weight (kDa): 40.037
UniProt ID(s): A0A143ZXB3
PDB ID(s): None
Isoelectric Point: 8.13
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001509 | NAD-dependent epimerase/dehydratase |
| InterPro | IPR028614 | GDP-L-fucose synthase/GDP-L-colitose synthase |
| InterPro | IPR036291 | NAD(P)-binding domain superfamily |
| PFam | PF01370 | NAD-dependent epimerase/dehydratase |
| Superfamily | SSF51735 | NAD(P)-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23615908 | Biosynthesis of GDP-fucose and other sugar nucleotides in the blood stages ofPlasmodium falciparum. | Sanz S, Bandini G, ..., Izquierdo L | 10.1074/jbc.M112.439828 |