Product Description: transcriptional coactivator ADA2
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000123 | histone acetyltransferase complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003700 | DNA-binding transcription factor activity |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0003713 | transcription coactivator activity |
| Process | GO:0006338 | chromatin remodeling |
| Process | GO:0035066 | positive regulation of histone acetylation |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 1.52 | 0.39 |
| Trophozoite | possibly expressed | 1.70 | 0.26 |
| Schizont | expressed | 1.85 | 0.23 |
| Gametocyte | not expressed | 0.98 | 0.51 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1014600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.375 | MFS: -2.557 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1213000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJP9
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=2.35) with 3CLV (Global RMSD=27.31)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100940
Most Similar Human Ortholog: A0A087X2C8
TM-align score: 0.89 | RMSD: 0.95
Seq Identity: 0.41 | Length: 56 / 2578
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000173011 | transcriptional adaptor 2B |
| ENSG00000276234 | transcriptional adaptor 2A |
| ENSG00000277104 | transcriptional adaptor 2A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 30 | 129 | 72 | 172 |
| disruptive | 81 | 328 | 188 | 421 |
| missense | 47 | 284 | 170 | 371 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 52 | 254 | 103 | 150 |
| disruptive | 132 | 701 | 288 | 563 |
| missense | 81 | 583 | 251 | 435 |
PlasmoDB Total SNPs: 323
Non-coding: 107 | Synonymous: 120 | Nonsynonymous: 95 | Stop Codon: 1
Protein Length: 2578 | Molecular Weight (kDa): 300.254
PDB ID(s): None
Isoelectric Point: 8.94
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000433 | Zinc finger, ZZ-type |
| InterPro | IPR001005 | SANT/Myb domain |
| InterPro | IPR009057 | Homeobox-like domain superfamily |
| InterPro | IPR041983 | ADA2-like, zinc finger, ZZ-type |
| PFam | PF00249 | SANT/Myb domain |
| PFam | PF00569 | Zinc finger, ZZ-type |
| Superfamily | SSF46689 | Homeobox-like domain superfamily |
| Superfamily | SSF57850 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15075257 | Plasmodium falciparum histone acetyltransferase, a yeast GCN5 homologue involvedin chromatin remodeling. | Fan Q, An L, Cui L | 10.1128/EC.3.2.264-276.2004 |
| 15246536 | PfADA2, a Plasmodium falciparum homologue of the transcriptional coactivator ADA2and its in vivo association with the histone acetyltransferase PfGCN5. | Fan Q, An L, Cui L | 10.1016/j.gene.2004.04.005 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31728527 | Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. | Hoeijmakers WAM, Miao J, ..., Bartfai R | 10.1093/nar/gkz1044 |
| 34403450 | A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion andvirulence in the malaria parasite Plasmodium falciparum. | Miao J, Wang C, ..., Cui L | 10.1371/journal.ppat.1009351 |