Product Description: prohibitin 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0005515 | protein binding |
| Process | GO:0009987 | cellular process |
| Process | GO:0007005 | mitochondrion organization |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.07 | 0.97 |
| Trophozoite | expressed | 0.34 | 0.80 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1014700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.166 | MFS: -3.223 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1213100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1213100)
Modification: Tagged | RMgm-4441
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJP8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O35129 | Prohibitin-2 | HOGENOM, OMA, OrthoDB | CHEMBL4293894 |
Ortholog Group (OrthoMCL): OG6_101763
Most Similar Human Ortholog: F5GY37
TM-align score: 0.88 | RMSD: 1.94
Seq Identity: 0.50 | Length: 255 / 304
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000215021 | prohibitin 2 |
Protein Length: 304 | Molecular Weight (kDa): 34.794
UniProt ID(s): C4N895, C4N897, C4N8A1, C4N8A2, C4N8A9, Q8IJP8
PDB ID(s): None
Isoelectric Point: 10.27
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000163 | Prohibitin |
| InterPro | IPR001107 | Band 7 domain |
| InterPro | IPR036013 | Band 7/SPFH domain superfamily |
| PFam | PF01145 | Band 7 domain |
| Superfamily | SSF117892 | Band 7/SPFH domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 24 | 6 | 14 |
| disruptive | 1 | 12 | 5 | 18 |
| missense | 1 | 8 | 5 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 38 | 8 | 12 |
| disruptive | 2 | 32 | 14 | 32 |
| missense | 1 | 21 | 12 | 25 |
PlasmoDB Total SNPs: 28
Non-coding: 22 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29669282 | An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial MembranePotential. | Matz JM, Goosmann C, Matuschewski K, Kooij TWA | 10.1016/j.celrep.2018.03.088 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38142736 | Prohibitin 2: A key regulator of cell function | Zhang B, Li W, ..., Yuan X | 10.1016/j.lfs.2023.122371 |
| 38176501 | Selection and identification of a prohibitin 2-binding DNA aptamer for tumor tissue imaging and targeted chemotherapy | Qiao Y, Shi Y, ..., Yuan B | 10.1016/j.ijbiomac.2023.129002 |