About Gene List

PF3D7_1014900 (KIC8)

Genome location: Pf3D7_10_v3:600,950..608,809(-)

Genome classification: Core

Function and Localization

Product Description: protein KIC8

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.12 0.94
Trophozoite not expressed 0.41 0.78
Schizont not expressed 2.16 0.30
Gametocyte possibly expressed 0.71 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1014900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.585 | #Insertions: 14

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJP6

"Best" AlphaFill ligand hit: SNO ((2s)-2-(4-nitrophenyl)oxirane, Local RMSD=24.45) with 5YB5 (Global RMSD=30.14)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532890

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 86 68 138
disruptive 77 357 174 454
missense 60 342 164 421

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 20 173 109 150
disruptive 153 653 266 542
missense 121 604 249 469

PlasmoDB Total SNPs: 251

Non-coding: 53 | Synonymous: 102 | Nonsynonymous: 96 | Stop Codon: 0

Protein Information

Protein Length: 2279 | Molecular Weight (kDa): 267.984

UniProt ID(s): Q8IJP6

PDB ID(s): None

Isoelectric Point: 7.92

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108