Product Description: FAD synthetase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 2.7.7.2 (FAD synthase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003919 | FMN adenylyltransferase activity |
| Process | GO:0006747 | FAD biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | not expressed | 0.16 | 0.90 |
| Schizont | possibly expressed | 0.22 | 0.85 |
| Gametocyte | possibly expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1015000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.989 | MFS: -2.699 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1213400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1213400)
Modification: Disrupted | RMgm-3240
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJP5
"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=0.59) with 3G6K (Global RMSD=13.82)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.7.2 | FAD synthase | KIATPADPFADGTPGDPFMNNAD+NADH2-thio-FMNdiphosphate1-deaza-FMN... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102300
Most Similar Human Ortholog: Q5T190
TM-align score: 0.90 | RMSD: 1.27
Seq Identity: 0.36 | Length: 123 / 328
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000160688 | flavin adenine dinucleotide synthetase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 11 | 18 |
| disruptive | 10 | 22 | 15 | 33 |
| missense | 8 | 20 | 14 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 20 | 12 | 18 |
| disruptive | 13 | 49 | 24 | 56 |
| missense | 10 | 39 | 18 | 41 |
PlasmoDB Total SNPs: 86
Non-coding: 66 | Synonymous: 13 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 328 | Molecular Weight (kDa): 39.418
UniProt ID(s): Q8IJP5
PDB ID(s): None
Isoelectric Point: 7.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002500 | Phosphoadenosine phosphosulphate reductase |
| PFam | PF01507 | Phosphoadenosine phosphosulphate reductase |
| Superfamily | SSF52402 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |