Product Description: CWC16 domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071006 | U2-type catalytic step 1 spliceosome |
| Component | GO:0005634 | nucleus |
| Process | GO:0008380 | RNA splicing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | possibly expressed | 0.22 | 0.86 |
| Schizont | possibly expressed | 0.10 | 0.92 |
| Gametocyte | possibly expressed | 0.15 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1015100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.865 | MFS: -2.566 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJP4
"Best" AlphaFill ligand hit: UPG (uridine-5'-diphosphate-glucose, Local RMSD=0.89) with 7UBY (Global RMSD=20.70)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102870
Most Similar Human Ortholog: M0R2S3
TM-align score: 0.74 | RMSD: 2.49
Seq Identity: 0.33 | Length: 135 / 396
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105248 | YJU2 splicing factor homolog |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 20 | 11 | 30 |
| disruptive | 9 | 54 | 33 | 73 |
| missense | 7 | 54 | 32 | 65 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 39 | 21 | 28 |
| disruptive | 15 | 106 | 54 | 92 |
| missense | 12 | 100 | 48 | 75 |
PlasmoDB Total SNPs: 58
Non-coding: 18 | Synonymous: 23 | Nonsynonymous: 15 | Stop Codon: 2
Protein Length: 396 | Molecular Weight (kDa): 46.79
UniProt ID(s): Q8IJP4
PDB ID(s): None
Isoelectric Point: 8.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007590 | Saf4/Yju2 protein |
| PFam | PF04502 | Saf4/Yju2 protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |