About Gene List

PF3D7_1015400

Genome location: Pf3D7_10_v3:620,802..623,974(+)

Genome classification: Core

Function and Localization

Product Description: RMI1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.97
Trophozoite possibly expressed 0.79 0.57
Schizont possibly expressed 0.38 0.76
Gametocyte not expressed 0.22 0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1015400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.34 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1213800)

  • Relative Growth Rate: 0.60 ± 0.11
  • Confidence: 5.75

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1213800)

Modification: Disrupted | RMgm-3242

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJP1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533297

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 29 25 48
disruptive 25 111 73 164
missense 15 103 70 149

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 65 35 53
disruptive 40 233 111 189
missense 25 216 98 149

PlasmoDB Total SNPs: 130

Non-coding: 68 | Synonymous: 32 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 773 | Molecular Weight (kDa): 92.882

UniProt ID(s): Q8IJP1

PDB ID(s): None

Isoelectric Point: 7.41

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013894 RecQ mediated genome instability protein, N-terminal
PFam PF08585 RecQ mediated genome instability protein, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108