PF3D7_1015500

Genome location: Pf3D7_10_v3:623,873..626,190(-)

Genome classification: Core

Function and Localization

Product Description: nucleotidyltransferase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005634	nucleus
Function	GO:0016779	nucleotidyltransferase activity
Process	GO:0006397	mRNA processing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.17	0.89
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1015500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.05 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1447600)

Relative Growth Rate: 0.14 ± 0.11
Confidence: 5.84

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJP0

"Best" AlphaFill ligand hit: 2TM (cmpcpp, Local RMSD=0.02) with 6YWN (Global RMSD=3.46)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101058

Most Similar Human Ortholog: Q5VYT0

TM-align score: 0.88 | RMSD: 1.75

Seq Identity: 0.24 | Length: 123 / 615

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000083223	terminal uridylyl transferase 7
ENSG00000134744	terminal uridylyl transferase 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	29	13	31
disruptive	7	59	34	94
missense	4	56	32	86

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	54	24	33
disruptive	13	133	52	121
missense	9	122	43	99

PlasmoDB Total SNPs: 46

Non-coding: 18 | Synonymous: 20 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 615 | Molecular Weight (kDa): 72.618

UniProt ID(s): Q8IJP0

PDB ID(s): None

Isoelectric Point: 8.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR043519	Nucleotidyltransferase superfamily
PFam	PF19088	N/A
Superfamily	SSF81301	Nucleotidyltransferase superfamily
Superfamily	SSF81631