Product Description: heat shock protein 60
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0006457 | protein folding |
| Process | GO:0006626 | protein targeting to mitochondrion |
| Process | GO:0006986 | response to unfolded protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.21 | 0.90 |
| Trophozoite | expressed | 1.05 | 0.50 |
| Schizont | expressed | 0.16 | 0.90 |
| Gametocyte | expressed | 0.56 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1015600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.132 | MFS: -2.902 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1214000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJN9
"Best" AlphaFill ligand hit: AGS (phosphothiophosphoric acid-adenylate ester, Local RMSD=0.64) with 3E76 (Global RMSD=3.40)
No associated EC numbersOrthology to BindingDB Entries:
Ortholog Group (OrthoMCL): OG6_100393
Most Similar Human Ortholog: A0A7I2V599
TM-align score: 0.94 | RMSD: 1.58
Seq Identity: 0.53 | Length: 519 / 580
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000144381 | heat shock protein family D (Hsp60) member 1 |
Protein Length: 580 | Molecular Weight (kDa): 62.551
PDB ID(s): None
Isoelectric Point: 7.07
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001844 | Chaperonin Cpn60 |
| InterPro | IPR002423 | Chaperonin Cpn60/TCP-1 family |
| InterPro | IPR018370 | Chaperonin Cpn60, conserved site |
| InterPro | IPR027409 | GroEL-like apical domain superfamily |
| InterPro | IPR027410 | TCP-1-like chaperonin intermediate domain superfamily |
| InterPro | IPR027413 | GroEL-like equatorial domain superfamily |
| PFam | PF00118 | Chaperonin Cpn60/TCP-1 family |
| Superfamily | SSF48592 | GroEL-like equatorial domain superfamily |
| Superfamily | SSF52029 | GroEL-like apical domain superfamily |
| Superfamily | SSF54849 | TCP-1-like chaperonin intermediate domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 37 | 13 | 36 |
| disruptive | 1 | 7 | 7 | 26 |
| missense | 1 | 7 | 6 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 89 | 20 | 21 |
| disruptive | 4 | 26 | 25 | 62 |
| missense | 2 | 19 | 23 | 43 |
PlasmoDB Total SNPs: 82
Non-coding: 69 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9274871 | Molecular characterization and ultrastructural localization of Plasmodiumfalciparum Hsp 60. | Das A, Syin C, ..., Kumar N | https://pubmed.ncbi.nlm.nih.gov/9274871/ |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 26317863 | Characterization of Precursor PfHsp60 in Plasmodium falciparum Cytosol during ItsAsexual Development in Human Erythrocytes. | Padma Priya P, Grover M, Tatu US, Natarajan V | 10.1371/journal.pone.0136401 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38329114 | Glutamine sustains energy metabolism and alleviates liver injury in burn sepsisby promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4dependent protein deacetylation | Yang Y, Chen Q, ..., Peng X | 10.1080/13510002.2024.2312320 |
| 38382728 | Phthalate drives splenic inflammatory response via activating HSP60/TLR4/NLRP3signaling axis-dependent pyroptosis | Ge XR, Zhao Y, ..., Li JL | 10.1016/j.envpol.2024.123610 |