PF3D7_1015700

Genome location: Pf3D7_10_v3:629,909..632,135(-)

Genome classification: Core

Function and Localization

Product Description: tubulin binding cofactor c, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Process	GO:0006457	protein folding
Process	GO:0007021	tubulin complex assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	nd	nd
Trophozoite	no data	nd	nd
Schizont	no data	nd	nd
Gametocyte	no data	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1015700.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.171 | MFS: -3.311 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1214100)

Relative Growth Rate: 0.06 ± 0.03
Confidence: 8.59

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXD1

"Best" AlphaFill ligand hit: NDP (nadph dihydro-nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.63) with 3JSU (Global RMSD=15.05)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102861

Most Similar Human Ortholog: Q15814

TM-align score: 0.56 | RMSD: 3.52

Seq Identity: 0.18 | Length: 219 / 335

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000124659	tubulin folding cofactor C

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	12	4	23
disruptive	13	24	14	30
missense	13	24	14	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	24	11	16
disruptive	19	56	27	56
missense	15	47	25	48

PlasmoDB Total SNPs: 116

Non-coding: 96 | Synonymous: 15 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 335 | Molecular Weight (kDa): 39.483

UniProt ID(s): C6S3C6

PDB ID(s): None

Isoelectric Point: 5.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006599	CARP motif
InterPro	IPR012945	Tubulin binding cofactor C-like domain
InterPro	IPR027684	Tubulin-specific chaperone C
PFam	PF07986	Tubulin binding cofactor C-like domain
Superfamily	N/A	N/A