PF3D7_1016000

Genome location: Pf3D7_10_v3:640,507..643,699(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	not expressed	0.07	0.96
Schizont	expressed	0.61	0.71
Gametocyte	expressed	0.43	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1016000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.642 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1214400)

Relative Growth Rate: 0.98 ± 0.12
Confidence: 5.67

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1214400)

Modification: Disrupted | RMgm-3247

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJN6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532822

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	19	15	31
disruptive	6	46	36	62
missense	6	46	36	60

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	43	23	32
disruptive	15	94	64	86
missense	13	88	60	74

PlasmoDB Total SNPs: 103

Non-coding: 85 | Synonymous: 7 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 453 | Molecular Weight (kDa): 53.934

UniProt ID(s): Q8IJN6

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A