About Gene List

PF3D7_1016100

Genome location: Pf3D7_10_v3:643,558..644,331(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.01 0.99
Schizont not expressed 0.01 0.99
Gametocyte not expressed 0.13 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1016100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.301 | MFS: -3.653 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJN5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532997

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 9 6 8
disruptive 7 30 24 37
missense 5 30 20 32

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 17 9 14
disruptive 16 71 35 55
missense 10 59 28 40

PlasmoDB Total SNPs: 15

Non-coding: 0 | Synonymous: 8 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 257 | Molecular Weight (kDa): 30.008

UniProt ID(s): Q8IJN5

PDB ID(s): None

Isoelectric Point: 9.23

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094