PF3D7_1016200

Genome location: Pf3D7_10_v3:645,557..647,959(+)

Genome classification: Core

Function and Localization

Product Description: Rab3 GTPase-activating protein non-catalytic subunit, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0043087	regulation of GTPase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.52	0.74
Trophozoite	not expressed	0.47	0.72
Schizont	not expressed	0.21	0.86
Gametocyte	not expressed	0.42	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1016200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.218 | MFS: -3.346 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJN4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532955

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	22	5	23
disruptive	8	16	21	51
missense	7	16	21	46

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	37	11	23
disruptive	13	62	43	101
missense	10	48	39	70

PlasmoDB Total SNPs: 120

Non-coding: 89 | Synonymous: 21 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 560 | Molecular Weight (kDa): 66.383

UniProt ID(s): Q8IJN4

PDB ID(s): None

Isoelectric Point: 8.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026059	Rab3-GAP regulatory subunit
InterPro	IPR032839	Rab3-GAP regulatory subunit, N-terminal
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	PF14655	Rab3-GAP regulatory subunit, N-terminal
Superfamily	SSF50978	WD40-repeat-containing domain superfamily