Product Description: GBP130 protein
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0020030 | infected host cell surface knob |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.44 | 0.52 |
| Trophozoite | expressed | 3.56 | 0.07 |
| Schizont | expressed | 0.89 | 0.62 |
| Gametocyte | expressed | 0.94 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1016300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.841 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I6U8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 14 | 9 | 20 |
| disruptive | 6 | 20 | 15 | 44 |
| missense | 6 | 19 | 12 | 39 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 27 | 12 | 13 |
| disruptive | 9 | 70 | 23 | 62 |
| missense | 6 | 53 | 20 | 44 |
PlasmoDB Total SNPs: 448
Non-coding: 199 | Synonymous: 187 | Nonsynonymous: 62 | Stop Codon: 0
Protein Length: 824 | Molecular Weight (kDa): 95.844
UniProt ID(s): A0A143ZWU2, Q25767, Q25858, Q8I6U8, Q9TY78, Q9U591
PDB ID(s): None
Isoelectric Point: 4.77
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003681 | Glycophorin-binding protein |
| PFam | PF02526 | Glycophorin-binding protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 18614010 | Exported proteins required for virulence and rigidity of Plasmodiumfalciparum-infected human erythrocytes. | Maier AG, Rug M, ..., Cowman AF | 10.1016/j.cell.2008.04.051 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 28252383 | Plasmodium falciparum parasites deploy Rhop H2 into the host erythrocyte to obtainnutrients, grow and replicate | Counihan NA, Chisholm SA, ..., de Koning-Ward TF | 10.7554/eLife.23217 |
| 28981210 | Proteome and Structural Organization of the Knob Complex on the Surface of thePlasmodium Infected Red Blood Cell. | Alampalli SV, Grover M, ..., Acharya P | 10.1002/prca.201600177 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33774908 | Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. | Jonsdottir TK, Counihan NA, ..., Gilson PR | 10.1111/cmi.13332 |
| 1374714 | Transcription mapping of a 100 kb locus of Plasmodium falciparum identifies anintergenic region in which transcription terminates and reinitiates | Lanzer M, de Bruin D, Ravetch JV | 10.1002/j.1460-2075.1992.tb05248.x |
| 2404782 | Chemical crosslinking of Plasmodium falciparum glycoprotein, Pf200 (190-205 kDa),to the S-antigen at the merozoite surface | Perkins ME, Rocco LJ | 10.1016/0014-4894(90)90101-h |
| 10215026 | Mutational analysis identifies a five base pair cis-acting sequence essential forGBP130 promoter activity in Plasmodium falciparum | Horrocks P, Lanzer M | 10.1016/s0166-6851(98)00182-0 |
| 1684263 | A study of the genomic diversity of Plasmodium falciparum in Senegal. 2. Typingby the use of the polymerase chain reaction | Mercereau-Puijalon O, Fandeur T, ..., Sarthou JL | 10.1016/0001-706x(91)90080-4 |
| 28750796 | The N-terminal extension of the P. falciparum GBP130 signal peptide is irrelevantfor signal sequence function | Meyer C, Barniol L, Hiss JA, Przyborski JM | 10.1016/j.ijmm.2017.07.003 |
| 12567560 | Functional characterization of the 5' proximal flanking fragment of Plasmodiumfalciparum GBP130 gene | Wang XF, Miao J, ..., Xue CF | https://pubmed.ncbi.nlm.nih.gov/12567560/ |
| 15760658 | Recombinant and native Plasmodium falciparum TATA-binding-protein binds to aspecific TATA box element in promoter regions | Ruvalcaba-Salazar OK, del Carmen Ramirez-Estudillo M, ..., Hernandez-Rivas R | 10.1016/j.molbiopara.2005.01.002 |
| 15281443 | Effects of tetracycline operator element insertion on Plasmodium falciparumglycophorin binding protein 130 gene promoter activity | Wang XF, Xue CF, ..., Miao J | https://pubmed.ncbi.nlm.nih.gov/15281443/ |
| 2509909 | Specificities of antibodies that inhibit merozoite dispersal frommalaria-infected erythrocytes | Lyon JA, Thomas AW, Hall T, Chulay JD | 10.1016/0166-6851(89)90203-x |
| 3512098 | A tandemly repeated sequence determines the binding domain for an erythrocytereceptor binding protein of P. falciparum | Kochan J, Perkins M, Ravetch JV | 10.1016/0092-8674(86)90834-2 |
| 11269326 | Differences in nucleosome organization over episomally located plasmids coincideswith aberrant promoter activity in P. falciparum | Horrocks P, Lanzer M | 10.1016/s1383-5769(99)00002-1 |
| 1719834 | Immunization of owl monkeys with a recombinant protein containing repeatedepitopes of a Plasmodium falciparum glycophorin-binding protein | Aronson NE, Silverman C, ..., Chulay JD | 10.4269/ajtmh.1991.45.548 |
| 8303938 | Immunogenicity and antigenicity of a Plasmodium falciparum protein fraction(90-110 kDa) able to protect squirrel monkeys against asexual blood stages | Bonnefoy S, Gysin J, ..., Mercereau-Puijalon O | 10.1016/0264-410x(94)90008-6 |