About Gene List

PF3D7_1016500

Genome location: Pf3D7_10_v3:660,965..664,407(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTc), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.09 0.96
Trophozoite possibly expressed 0.07 0.96
Schizont not expressed 0.04 0.98
Gametocyte possibly expressed 0.21 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1016500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -2.69 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJN2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_144691

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 15 14 29
disruptive 31 67 39 123
missense 25 65 36 109

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 32 27 43
disruptive 53 172 85 201
missense 37 139 66 130

PlasmoDB Total SNPs: 182

Non-coding: 74 | Synonymous: 68 | Nonsynonymous: 37 | Stop Codon: 3

Protein Information

Protein Length: 767 | Molecular Weight (kDa): 92.411

UniProt ID(s): Q8IJN2

PDB ID(s): None

Isoelectric Point: 9.47

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12