About Gene List

PF3D7_1016600

Genome location: Pf3D7_10_v3:665,222..667,054(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTc), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.10 0.95
Trophozoite possibly expressed 0.08 0.94
Schizont not expressed 0.04 0.97
Gametocyte possibly expressed 0.10 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1016600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.074 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3C7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215350

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 17 4 14
disruptive 3 28 21 39
missense 3 28 20 38

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 23 14 20
disruptive 5 83 35 97
missense 4 73 28 67

PlasmoDB Total SNPs: 102

Non-coding: 92 | Synonymous: 2 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 296 | Molecular Weight (kDa): 36.266

UniProt ID(s): C6S3C7

PDB ID(s): None

Isoelectric Point: 5.04

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
25106850 A conserved domain targets exported PHISTb family proteins to the periphery ofPlasmodium infected erythrocytes. Tarr SJ, Moon RW, Hardege I, Osborne AR 10.1016/j.molbiopara.2014.07.011