About Gene List

PF3D7_1016700

Genome location: Pf3D7_10_v3:668,764..673,661(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTc), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 1.01 0.55
Trophozoite expressed 0.14 0.92
Schizont not expressed 0.13 0.93
Gametocyte not expressed 0.20 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1016700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.631 | MFS: -2.52 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJN1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215350

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 34 19 39
disruptive 43 156 70 168
missense 32 134 65 148

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 73 24 40
disruptive 85 258 129 239
missense 60 220 114 184

PlasmoDB Total SNPs: 240

Non-coding: 133 | Synonymous: 37 | Nonsynonymous: 70 | Stop Codon: 0

Protein Information

Protein Length: 830 | Molecular Weight (kDa): 98.793

UniProt ID(s): Q8IJN1

PDB ID(s): None

Isoelectric Point: 7.35

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g