Genome location: Pf3D7_10_v3:680,750..683,255(-)
Genome classification: Core
Product Description: early transcribed membrane protein 10.3
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020005 | symbiont-containing vacuole membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.27 | 0.88 |
| Trophozoite | expressed | 1.22 | 0.44 |
| Schizont | expressed | 1.12 | 0.43 |
| Gametocyte | expressed | 3.43 | 0.05 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1016900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.519 | MFS: -2.338 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0501200)
Modification: Disrupted | RMgm-5210
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJM9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 148
Non-coding: 135 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 108 | Molecular Weight (kDa): 11.961
UniProt ID(s): Q8IJM9
PDB ID(s): None
Isoelectric Point: 9.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006389 | Early transcribed membrane protein (ETRAMP) |
| PFam | PF09716 | Early transcribed membrane protein (ETRAMP) |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20228203 | Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorousvacuole and exported protein in blood stages. | Mackellar DC, O'Neill MT, ..., Kappe SH | 10.1128/EC.00336-09 |
| 34715088 | Plasmodium early transcribed membrane proteins appear tailored to the host rangeof malaria parasites | Brandsma AM, Hilmer C, ..., Montagna GN | 10.1016/j.ijpara.2021.08.005 |
| 34252120 | Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccineantigens using chimeric rodent parasites | Kolli SK, Salman AM, ..., Janse CJ | 10.1371/journal.pone.0254498 |
| 31058097 | A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes,Sporozoites, and Liver-Stages | Marin-Mogollon C, Salman AM, ..., Khan SM | 10.3389/fcimb.2019.00096 |