Product Description: rhoptry neck protein 12
SignalP Peptide: MKRVYTCLCFICLFFLCILKGVYN
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0009986 | cell surface |
| Component | GO:0020009 | microneme |
| Component | GO:1990225 | rhoptry neck |
| Component | GO:0020003 | symbiont-containing vacuole |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.09 | 0.94 |
| Schizont | expressed | 1.81 | 0.29 |
| Gametocyte | not expressed | 0.09 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1017100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.13 | MFS: -2.976 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0501400)
Modification: Disrupted | RMgm-4544
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJM8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 179
Non-coding: 166 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 310 | Molecular Weight (kDa): 36.405
UniProt ID(s): Q8IJM8
PDB ID(s): None
Isoelectric Point: 5.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 23937520 | RON12, a novel Plasmodium-specific rhoptry neck protein important for parasiteproliferation. | Knuepfer E, Suleyman O, ..., Holder AA | 10.1111/cmi.12181 |
| 30342119 | Antibodies against a Plasmodium falciparum RON12 inhibit merozoite invasion intoerythrocytes. | Ito D, Takashima E, ..., Tsuboi T | 10.1016/j.parint.2018.10.006 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 30290224 | Plasmodium RON12 localizes to the rhoptry body in sporozoites | Oda-Yokouchi Y, Tachibana M, ..., Tsuboi T | 10.1016/j.parint.2018.10.001 |
| 24070999 | Identification of three novel Toxoplasma gondii rhoptry proteins | Camejo A, Gold DA, ..., Saeij JP | 10.1016/j.ijpara.2013.08.002 |