Product Description: enoyl-CoA hydratase-related protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.2.4 (3-hydroxyisobutyryl-CoA hydrolase);4.2.1.17 (Enoyl-CoA hydratase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.05 | 0.96 |
| Schizont | expressed | 0.05 | 0.97 |
| Gametocyte | possibly expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1017200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.177 | MFS: -3.347 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJM7
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.2.4 | 3-hydroxyisobutyryl-CoA hydrolase | acetyl-CoAmalonyl-CoApropionyl-CoAn-valeryl-CoAisobutyryl-CoAacetoacetyl-CoADL-methylmalonyl-CoADL-3-hydroxybutyryl-CoA |
| 4.2.1.17 | enoyl-CoA hydratase | CoANEMacetyl-CoAoctanoyl-CoAcrotonyl-CoAdecenoyl-CoAhexenoyl-CoAiodoacetamidepropionyl-CoApropanoyl-CoA3-octynoyl-CoAacetoacetyl-CoA... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 20 | 6 | 19 |
| disruptive | 1 | 44 | 25 | 76 |
| missense | 1 | 44 | 25 | 74 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 30 | 16 | 45 |
| disruptive | 7 | 91 | 63 | 94 |
| missense | 6 | 83 | 60 | 77 |
PlasmoDB Total SNPs: 48
Non-coding: 22 | Synonymous: 20 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 530 | Molecular Weight (kDa): 62.908
UniProt ID(s): Q8IJM7
PDB ID(s): None
Isoelectric Point: 8.75
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR029045 | ClpP/crotonase-like domain superfamily |
| InterPro | IPR032259 | Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type |
| PFam | PF16113 | Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type |
| Superfamily | SSF52096 | ClpP/crotonase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |