About Gene List

PF3D7_1017500 (ELC)

Genome location: Pf3D7_10_v3:701,258..703,707(+)

Genome classification: Core

Function and Localization

Product Description: myosin essential light chain ELC

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface
Component GO:0070258 inner membrane pellicle complex
Component GO:0005634 nucleus
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.68 0.73
Trophozoite not expressed 0.08 0.95
Schizont possibly expressed 0.34 0.85
Gametocyte expressed 0.19 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1017500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.558 | MFS: -3.515 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0501800)

  • Relative Growth Rate: 0.12 ± 0.27
  • Confidence: 4.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJM4

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=8.32) with 4DKJ (Global RMSD=11.05)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533064

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 158

Non-coding: 154 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 134 | Molecular Weight (kDa): 15.677

UniProt ID(s): Q8IJM4

PDB ID(s): 6TJ3, 6TJ4, 6YCY, 6ZN3, 8CDQ

Isoelectric Point: 4.75

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011992 EF-hand domain pair
PFam N/A N/A
Superfamily SSF47473 EF-hand domain pair

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
28759593 Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodiumvivax salivary gland sporozoites. Swearingen KE, Lindner SE, ..., Mikolajczak SA https://pubmed.ncbi.nlm.nih.gov/28759593/
28893907 Compositional and expression analyses of the glideosome during the Plasmodiumlife cycle reveal an additional myosin light chain required for maximum motility. Green JL, Wall RJ, ..., Holder AA 10.1074/jbc.M117.802769
33046215 Full-length Plasmodium falciparum myosin A and essential light chain Pf ELCstructures provide new anti-malarial targets Moussaoui D, Robblee JP, ..., Houdusse A 10.7554/eLife.60581