PF3D7_1017700

Genome location: Pf3D7_10_v3:708,922..711,037(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.11	0.94
Trophozoite	expressed	0.15	0.91
Schizont	possibly expressed	0.18	0.88
Gametocyte	expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1017700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.344 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJM2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533552

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	21	15	26
disruptive	37	92	45	120
missense	17	57	33	85

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	43	19	29
disruptive	76	191	72	147
missense	26	127	46	85

PlasmoDB Total SNPs: 203

Non-coding: 121 | Synonymous: 48 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 439 | Molecular Weight (kDa): 53.24

UniProt ID(s): Q8IJM2

PDB ID(s): None

Isoelectric Point: 10.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A