About Gene List

PF3D7_1017800

Genome location: Pf3D7_10_v3:710,430..714,997(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0080008 Cul4-RING E3 ubiquitin ligase complex
Component GO:0005737 cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.25 0.88
Trophozoite expressed 0.64 0.65
Schizont expressed 0.22 0.85
Gametocyte expressed 0.63 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1017800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.183 | MFS: -2.746 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJM1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533248

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 15 50 32 69
disruptive 29 105 71 209
missense 15 88 61 177

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 22 113 50 69
disruptive 58 279 147 309
missense 30 220 107 229

PlasmoDB Total SNPs: 147

Non-coding: 44 | Synonymous: 74 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 1136 | Molecular Weight (kDa): 137.41

UniProt ID(s): Q8IJM1

PDB ID(s): None

Isoelectric Point: 9.67

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094