PF3D7_1018100

Genome location: Pf3D7_10_v3:720,551..721,399(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1018100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.975 | MFS: -2.047 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJL9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532344

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	12	7	24
disruptive	8	38	24	61
missense	7	38	22	57

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	32	11	19
disruptive	15	89	32	86
missense	11	79	30	65

PlasmoDB Total SNPs: 12

Non-coding: 0 | Synonymous: 5 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 282 | Molecular Weight (kDa): 33.902

UniProt ID(s): Q8IJL9

PDB ID(s): None

Isoelectric Point: 5.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A