PF3D7_1018300

Genome location: Pf3D7_10_v3:729,698..733,223(-)

Genome classification: Core

Function and Localization

Product Description: peptidase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	1.10	0.51
Trophozoite	not expressed	0.69	0.62
Schizont	expressed	0.29	0.82
Gametocyte	expressed	0.57	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1018300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.739 | MFS: -2.359 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0502600)

Relative Growth Rate: 0.10 ± 0.20
Confidence: 4.66

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3D0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_124535

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	42	26	63
disruptive	32	105	59	181
missense	28	90	49	152

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	90	46	72
disruptive	53	279	121	293
missense	44	220	93	164

PlasmoDB Total SNPs: 171

Non-coding: 56 | Synonymous: 67 | Nonsynonymous: 48 | Stop Codon: 0

Protein Information

Protein Length: 1015 | Molecular Weight (kDa): 118.419

UniProt ID(s): C6S3D0, Q9GVA9

PDB ID(s): None

Isoelectric Point: 5.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR021109	Aspartic peptidase domain superfamily
InterPro	IPR039755	TBC1 domain family member 23
PFam	N/A	N/A
Superfamily	SSF50630	Aspartic peptidase domain superfamily