PF3D7_1018400

Genome location: Pf3D7_10_v3:734,360..735,786(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.14	0.93
Trophozoite	possibly expressed	0.07	0.96
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.98	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1018400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -2.723 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJL7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533430

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	9	9	16
disruptive	7	9	8	17
missense	7	9	8	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	23	11	15
disruptive	12	35	20	45
missense	8	26	15	31

PlasmoDB Total SNPs: 101

Non-coding: 91 | Synonymous: 5 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 199 | Molecular Weight (kDa): 24.399

UniProt ID(s): Q8IJL7

PDB ID(s): None

Isoelectric Point: 10.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A