Product Description: pre-mRNA-splicing factor RDS3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005686 | U2 snRNP |
| Component | GO:0071011 | precatalytic spliceosome |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0000245 | spliceosomal complex assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.14 | 0.93 |
| Trophozoite | expressed | 0.25 | 0.85 |
| Schizont | expressed | 0.08 | 0.95 |
| Gametocyte | expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1018500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.992 | MFS: -1.744 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0502700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3D1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102593
Most Similar Human Ortholog: Q7RTV0
TM-align score: 0.96 | RMSD: 0.89
Seq Identity: 0.85 | Length: 107 / 111
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100410 | PHD finger protein 5A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 1 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 1 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 142
Non-coding: 136 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 111 | Molecular Weight (kDa): 12.54
UniProt ID(s): C6S3D1
PDB ID(s): None
Isoelectric Point: 7.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005345 | PHF5-like |
| PFam | PF03660 | PHF5-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12871902 | Genetic interactions with CLF1 identify additional pre-mRNA splicing factors anda link between activators of yeast vesicular transport and splicing | Vincent K, Wang Q, ..., Rymond BC | 10.1093/genetics/164.3.895 |