PF3D7_1018700

Genome location: Pf3D7_10_v3:744,974..749,556(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.64	0.70
Trophozoite	expressed	0.65	0.63
Schizont	expressed	0.67	0.61
Gametocyte	expressed	0.81	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1018700

Resistome Missense Mutations: Q76K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.158 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJL5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533406

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	37	19	40
disruptive	27	109	55	133
missense	16	91	51	104

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	71	25	45
disruptive	63	225	84	234
missense	36	174	61	142

PlasmoDB Total SNPs: 180

Non-coding: 127 | Synonymous: 31 | Nonsynonymous: 22 | Stop Codon: 0

Protein Information

Protein Length: 619 | Molecular Weight (kDa): 72.959

UniProt ID(s): Q8IJL5

PDB ID(s): None

Isoelectric Point: 9.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A