PF3D7_1018800

Genome location: Pf3D7_10_v3:749,573..753,145(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	expressed	0.20	0.88
Schizont	possibly expressed	0.12	0.93
Gametocyte	expressed	0.63	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1018800

Resistome Missense Mutations: D213G

Resistome Compounds with Missense Mutations: MMV009108

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: 0.655 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0503000)

Modification: Disrupted | RMgm-4212

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJL4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532536

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	29	17	45
disruptive	17	81	46	108
missense	15	78	46	91

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	64	30	52
disruptive	49	199	93	200
missense	33	159	79	137

PlasmoDB Total SNPs: 285

Non-coding: 208 | Synonymous: 49 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 708 | Molecular Weight (kDa): 85.55

UniProt ID(s): Q8IJL4

PDB ID(s): None

Isoelectric Point: 9.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003734	Domain of unknown function DUF155
PFam	PF02582	Domain of unknown function DUF155
Superfamily	N/A	N/A