PF3D7_1018900

Genome location: Pf3D7_10_v3:752,748..755,185(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.19	0.90
Trophozoite	expressed	0.20	0.88
Schizont	possibly expressed	0.08	0.94
Gametocyte	possibly expressed	0.30	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1018900

Resistome Missense Mutations: K308N

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.237 | MFS: -2.728 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJL3

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.98) with 6JWQ (Global RMSD=8.36)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532554

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	41	15	37
disruptive	30	73	57	110
missense	25	72	52	106

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	63	21	50
disruptive	48	190	82	215
missense	38	166	68	136

PlasmoDB Total SNPs: 85

Non-coding: 19 | Synonymous: 41 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 716 | Molecular Weight (kDa): 86.062

UniProt ID(s): Q8IJL3

PDB ID(s): None

Isoelectric Point: 8.65

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A