PF3D7_1019100

Genome location: Pf3D7_10_v3:765,846..772,310(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.14	0.92
Schizont	possibly expressed	1.41	0.43
Gametocyte	expressed	1.26	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1019100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.059 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0503300)

Modification: Disrupted | RMgm-1947

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJL1

"Best" AlphaFill ligand hit: NDP (nadph dihydro-nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.09) with 8JFB (Global RMSD=48.59)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215351

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	26	70	41	109
disruptive	105	300	177	384
missense	74	238	156	312

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	136	75	143
disruptive	195	626	260	530
missense	120	493	206	375

PlasmoDB Total SNPs: 373

Non-coding: 61 | Synonymous: 146 | Nonsynonymous: 165 | Stop Codon: 1

Protein Information

Protein Length: 1928 | Molecular Weight (kDa): 229.174

UniProt ID(s): Q8IJL1

PDB ID(s): None

Isoelectric Point: 9.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A