About Gene List

PF3D7_1019400

Genome location: Pf3D7_10_v3:785,374..787,414(+)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L30e, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022625 cytosolic large ribosomal subunit
Component GO:0005634 nucleus
Function GO:0003723 RNA binding
Function GO:0003735 structural constituent of ribosome
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.32 0.85
Trophozoite expressed 0.35 0.80
Schizont expressed 0.07 0.95
Gametocyte expressed 0.13 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1019400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.519 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0503600)

  • Relative Growth Rate: 0.10 ± 0.09
  • Confidence: 6.16

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJK8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100932

Most Similar Human Ortholog: E5RI99

TM-align score: 0.91 | RMSD: 1.46

Seq Identity: 0.58 | Length: 104 / 108

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000156482 ribosomal protein L30

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 162

Non-coding: 159 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 108 | Molecular Weight (kDa): 11.775

UniProt ID(s): Q8IJK8

PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD

Isoelectric Point: 9.91

Protein Domain Annotations:

Source Family ID Description
InterPro IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
InterPro IPR022991 Ribosomal protein L30e, conserved site
InterPro IPR029064 50S ribosomal protein L30e-like
InterPro IPR039109 Ribosomal protein L30/YlxQ
PFam PF01248 Ribosomal protein L7Ae/L30e/S12e/Gadd45
Superfamily SSF55315 50S ribosomal protein L30e-like

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596