PF3D7_1019600

Genome location: Pf3D7_10_v3:795,758..800,122(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	possibly expressed	0.24	0.85
Schizont	expressed	0.91	0.52
Gametocyte	expressed	0.63	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1019600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.196 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0503800)

Relative Growth Rate: 0.90 ± 0.12
Confidence: 5.66

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0503800)

Modification: Disrupted | RMgm-1951

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJK6

"Best" AlphaFill ligand hit: PLP (pyridoxal-5'-phosphate, Local RMSD=15.09) with 4DGT (Global RMSD=20.78)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533142

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	29	56	34	68
disruptive	140	220	96	243
missense	64	128	69	173

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	44	105	42	70
disruptive	195	375	135	365
missense	81	242	100	230

PlasmoDB Total SNPs: 329

Non-coding: 74 | Synonymous: 153 | Nonsynonymous: 102 | Stop Codon: 0

Protein Information

Protein Length: 1210 | Molecular Weight (kDa): 145.834

UniProt ID(s): Q8IJK6

PDB ID(s): None

Isoelectric Point: 6.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF50729	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104