About Gene List

PF3D7_1019700

Genome location: Pf3D7_10_v3:800,211..803,696(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000123 histone acetyltransferase complex
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.97
Trophozoite not expressed 0.48 0.73
Schizont not expressed 0.72 0.61
Gametocyte possibly expressed 1.06 0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1019700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.704 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJK5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125034

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 13 21 16 46
disruptive 85 135 61 147
missense 35 79 45 107

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 17 44 36 53
disruptive 135 215 88 208
missense 48 155 62 146

PlasmoDB Total SNPs: 401

Non-coding: 7 | Synonymous: 150 | Nonsynonymous: 242 | Stop Codon: 2

Protein Information

Protein Length: 1074 | Molecular Weight (kDa): 128.215

UniProt ID(s): Q8IJK5

PDB ID(s): None

Isoelectric Point: 5

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
34403450 A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion andvirulence in the malaria parasite Plasmodium falciparum. Miao J, Wang C, ..., Cui L 10.1371/journal.ppat.1009351