About Gene List

PF3D7_1020000 (RBM34)

Genome location: Pf3D7_10_v3:810,485..813,996(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein 34, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.39 0.82
Trophozoite expressed 0.61 0.66
Schizont expressed 0.20 0.88
Gametocyte expressed 1.07 0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1020000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.323 | MFS: -2.72 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJK1

"Best" AlphaFill ligand hit: M2M (1-methoxy-2-(2-methoxyethoxy)ethane, Local RMSD=3.52) with 4ED5 (Global RMSD=12.91)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103046

Most Similar Human Ortholog: P42696

TM-align score: 0.56 | RMSD: 3.63

Seq Identity: 0.31 | Length: 214 / 322

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000188739 RNA binding motif protein 34

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 19 9 18
disruptive 4 43 16 33
missense 4 36 16 29

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 31 18 27
disruptive 15 90 41 80
missense 9 75 34 50

PlasmoDB Total SNPs: 317

Non-coding: 297 | Synonymous: 17 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 322 | Molecular Weight (kDa): 37.558

UniProt ID(s): Q8IJK1

PDB ID(s): None

Isoelectric Point: 10.65

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000504 RNA recognition motif domain
InterPro IPR035979 RNA-binding domain superfamily
PFam PF00076 RNA recognition motif domain
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104