PF3D7_1020100

Genome location: Pf3D7_10_v3:813,999..815,283(-)

Genome classification: Core

Function and Localization

Product Description: flagellar outer arm dynein-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005868	cytoplasmic dynein complex
Function	GO:0045505	dynein intermediate chain binding
Process	GO:0007018	microtubule-based movement

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.08	0.95
Gametocyte	no data	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1020100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.146 | MFS: -2.531 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3D2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101498

Most Similar Human Ortholog: Q8TF09

TM-align score: 0.97 | RMSD: 0.84

Seq Identity: 0.56 | Length: 96 / 101

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000125971	dynein light chain roadblock-type 1
ENSG00000168589	dynein light chain roadblock-type 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 80

Non-coding: 75 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 101 | Molecular Weight (kDa): 11.556

UniProt ID(s): C6S3D2

PDB ID(s): None

Isoelectric Point: 6.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004942	Roadblock/LAMTOR2 domain
InterPro	IPR016561	Dynein light chain roadblock-type 1/2
PFam	PF03259	Roadblock/LAMTOR2 domain
Superfamily	SSF103196	N/A