PF3D7_1020300

Genome location: Pf3D7_10_v3:819,637..822,447(+)

Genome classification: Core

Function and Localization

Product Description: cytoplasmic dynein intermediate chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005868	cytoplasmic dynein complex
Function	GO:0045504	dynein heavy chain binding
Function	GO:0045503	dynein light chain binding
Function	GO:0003777	microtubule motor activity
Process	GO:0007018	microtubule-based movement
Process	GO:0010970	transport along microtubule

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	possibly expressed	0.03	0.98
Schizont	possibly expressed	0.24	0.85
Gametocyte	expressed	0.77	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1020300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.409 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJJ9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101571

Most Similar Human Ortholog: A0A0A0MTG2

TM-align score: 0.76 | RMSD: 3.43

Seq Identity: 0.32 | Length: 455 / 769

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000077380	dynein cytoplasmic 1 intermediate chain 2
ENSG00000158560	dynein cytoplasmic 1 intermediate chain 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	27	25	67
disruptive	9	58	27	122
missense	6	53	24	111

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	68	46	67
disruptive	26	125	66	177
missense	13	107	60	141

PlasmoDB Total SNPs: 105

Non-coding: 44 | Synonymous: 31 | Nonsynonymous: 29 | Stop Codon: 1

Protein Information

Protein Length: 769 | Molecular Weight (kDa): 89.222

UniProt ID(s): Q8IJJ9

PDB ID(s): None

Isoelectric Point: 5.66

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104